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KMID : 0387420010120020053
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Korean Society of Oriental Neuropsychiatry
2001 Volume.12 No. 2 p.53 ~ p.68
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The Effect of Guibiondamtang(歸脾溫膽湯) in an Animal Model of Depression using Chronic Mild Stress
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Kim Jong-Woo
Hwang Wei-Wan
Kim Hyun-Taek
Kwak So-Young
Kim Min-Jeoung
Cha Youn-Ju
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Abstract
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This study was performed to investigate the anti-depression effect of Guibiondamtang in rat model of depression. The rats in the experiment were stratified into 3 groups, ie, Guibiondamtang, saline, normal (non-stressed) groups. Chronic exposure to mild unpredictable stress such as white noise, flashing lights and restriction of food and water, causes the behavioral symptoms correspondent to depression. Consumption of 1% sucrose solution fell in rats exposed to CMS for 4 weeks. In the open field test , the exploratory activity ie. locomotion and centering decreased after CMS. We then evaluated the sucrose consumption and activity during 4 weeks of treatment with experimental drugs. The results were as follows: 1) There was no relation between sucrose intake and weight. 2) The Guibiondamtang(歸脾溫膽湯) group reinstated sucrose consumption within 5-6 weeks while having no influence on sucrose intake in normal group. 3) The Guibiondamtang(歸脾溫膽湯) group restored some exploratory activity in the open field test. 4) The Guibiondamtang-group had a-reduced potentiated startle response.
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